A Bishop from Australia comes to Perry to ask him to take a case of a woman wrongly accused of manslaughter 22 years before. The case would involve the wealthy Mr. Brownley and the fact that his alleged granddaughter may be an imposter. With that, the Bishop leaves and is clubbed in his hotel room. Soon after, he leaves on a boat and Perry meets the woman - Ida Gilbert. Perry goes to see Mr. Brownley, but gets nowhere. Later that night, Brownley is to meet Ida, but he is shot by a woman who drops Ida's gun. Ida is arrested for the murder of Mr. Brownley and Perry gets involved.
The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.
When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
A very nervous man named Cartwright comes into Perry's office to have the neighbor arrested for his howling dog. He states that the howling is a sign that there is a death in the neighborhood. He also wants a will written giving his estate to the lady living at the neighbors house. It is all very mysterious and by the next day, his will is changed and Cartwright is missing, as is the lady of the house next door. Perry has a will and a retainer and must find out whether he has a client or a beneficiary.
Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.
The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.
A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...
An actor rigs a fake shooting on TV with the connivance of his friend, the show's host, but the practical joke goes wrong when the gun turns out to contain a live round.
Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives
A young woman from Las Vegas wants Perry Mason to defend her father.
After giving the District Attorney another stinging defeat, Perry plans to take a vacation in China. That is, he was, until Rhoda, his old flame, meets him at a restaurant. It seems that her husband Moxley, who had been allegedly dead for four years, is alive and demanding money as she has married into wealth. The case escalates when the police find the body of Moxley and charge her with the murder.
A hockey player of friend of Ken Malansky's is accused of murdering a team owner. Perry takes the case.
On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.
David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.
A woman suddenly disappears after an early morning walk, and her husband is accused of murder.
Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.
Perry and Della are finally married by his old friend, Judge Mary. They plan to go on a honeymoon, but before it can start, Perry is retained by a woman with a gun and $5000.
A con man who stages phony "lucky legs" beauty contests and leaves town with the money is found with a surgical knife in his heart by Mason.
Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.
A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.