Kaksi nuorta seikkailijaa tutustuu uusiin maihin, paljastaa muinaisia mysteerejä ja kohtaa ennennäkemättömiä pokémoneja – ja poképalloja!

In Tokyo, a weak, unassertive boy named Sena Kobayakawa enters the high school of his choice, Deimon Private Senior High School. Sena's only remarkable physical abilities are his running speed and agility, which are noted by the school's American football team captain Yoichi Hiruma. Hiruma forces Sena to join the Deimon Devil Bats football team as its running back. To protect his identity from other teams who want to recruit him, Sena is forced to publicly assume the role of the team secretary and enter the field under the pseudonym of "Eyeshield 21" wearing a helmet with an eyeshield to hide his features.

Nuori Thorfinn liittyy hänen isänsä murhanneen Askeladdin palkkasoturijoukkioon odottamaan sopivaa koston hetkeä Askeladdin keskittyessä poliittisiin juoniinsa.

Achikochi Audrey is a variety show lead by the comedic duo Audrey. Every week, different guests are invited to the show to consult with Audrey on whatever troubles they have been facing recently.

Yoshizaki Kaoruko, who had been a clinician at a university hospital, takes up a post at a medical examiner’s office after she is told by her professor to try to get experience. However, everyone from the supervising doctor Akita Shinya, director Yanagida Shuhei and assistant Yamashita Mieko are all individualistic characters. This does not bode well for the future. Meanwhile, Akita and Kaoruko are put in charge of the dead body of a popular model who fell to her death. The police consider it to be a suicide, but Akita is drawn to a subtle point .

The story is centered around three close friends, Kaori, Aya and Nao, who get together at a coffee house or their respective homes and engage in idle gossip.