In 2071, roughly fifty years after an accident with a hyperspace gateway made the Earth almost uninhabitable, humanity has colonized most of the rocky planets and moons of the Solar System. Amid a rising crime rate, the Inter Solar System Police (ISSP) set up a legalized contract system, in which registered bounty hunters, also referred to as "Cowboys", chase criminals and bring them in alive in return for a reward.

Kaname Chidori’s one of the most popular girls at her high school – unfortunately, it’s her growing popularity off campus she should be worrying about. Unbeknownst to Kaname, terrorists are plotting her abduction, believing she possesses the rare and coveted abilities of “the Whispered.” That’s where Sousuke Sagara enters the picture. He’s a hotshot soldier from the clandestine counter-terrorist organization known as Mithril – and he’s going undercover at Kaname’s school to try and keep her safe. He may be an ace in the cockpit of an Arm Slave mech, but there’s no training in the world that could prepare him for the warzone of high school.

In a futuristic world almost barren of life, mankind is confined to mechanized domed cities where A.I.’s control all aspects of life. In this world, humans are no longer born, they are manufactured in a production line; and alongside them live androids known as autoreivs. Within one of these domed sanctuaries named Romdeau lives Re-l Mayer, one of a few citizens who aren’t entirely prevented from thinking. Her grandfather's prominent position and the affection of the scientist Daedalus have left her more free will than is normally allowed, but Re-l has started to question the sanctity of the city and the citizens' perfect way of life. With mysterious beings known as proxies causing havoc and a man named Vincent causing great influence on her life, Re-l must travel outside of the city to find the answers she seeks and discover the mystery behind "the awakening".

Forty years ago, the minds of Paradigm City's inhabitants were wiped clean of all recollections of the past. Now, ruled by a powerful corporation and cut off from the rest of the world by desolate wastelands, Paradigm has become a virtual police state where Negotiators like Roger Smith keep the wheels of progress, commerce, and society turning.

Since the graduation of the senior members of the club, Takezou ends up being the sole member of the "Koto" (traditional Japanese string instrument) club. Now that the new school year has begun, Takezou will have to seek out new members into the club, or the club will become terminated. Out of nowhere, a new member barges into the near-abandoned club room, demanding to join the club. How will Takezou be able to keep his club alive and deal with this rascal of a new member?

Many centuries ago, man's Armageddon gave birth to the vampires' wrath. As man and immortal clash, a reality-shattering threat looms. Hope resides solely in a new breed of hunter operating under the Vatican's authority. The true battle between holiness and evil has begun.

Across the ocean on the tiny island kingdom of Barou the ancient god Neo Ranga awakens from his slumber. He is mysteriously drawn to Tokyo, and the three beautiful sisters - Minami, Ushio, and Yuuhi - who are unwittingly linked to the monster.

But instead of rolling out the red carpet, the military rolls out the weaponry, and things start to get nasty. The plot thickens: Why is Neo Ranga driven to Tokyo? Is he a messenger with a warning for humankind, or just a big boy out for a good time? And what's behind Ranga's mysterious eyes?

Outside the magical barriers lies a world overrun by fiery beasts known as Flame Demons, and the only ones who can protect humanity are the Fire Hunters. In the dark woods where the beasts roam is where Touko, a young villager, is rescued from attack by one of these skilled trackers, Koushi. But their meeting was no accident, and a new destiny begins.

Avid bookworm and college student Motosu Urano ends up dying in an unforeseen accident. This came right after the news that she would finally be able to work as a librarian as she had always dreamed of. When she regained consciousness, she was reborn as Main, the daughter of a poor soldier. She was in the town of Ehrenfest, which had a harsh class system. But as long as she had books, she didn't really need anything else. However, books were scarce and belonged only to the nobles. But that doesn't stop her, so she makes a decision... "If there aren't any books, I'll just create some."

During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality. Takes place in the same universe as Durarara (2010).

Louie, a brawny student at the mage's guild, is reluctantly accepted by three girls (Merrill-thief, Genie-fighter, and Melissa-priestess) as a companion for their adventuring party. As the foursome explore ruins, battle dark creatures, and make new friends, they also uncover a sinister plot within the kingdom.

In order to prevent the catastrophe called the Grand Fall, Rid Hershel and his companions Farah, Keel and Meredy have obtained the three Greater Spirits ("Craymels" in the game version) of Inferia. En route to Mount Farlos, Rid is kidnapped by the bounty hunter Marone Blucarno, and the party is compelled to head to Belcarnu, an archipelago far from the major cities of Inferia. A series of adventures forces them to remain on the islands, where a more immediate threat to Inferia sleeps.

Yuri Ishikawa and her team try to crack unresolved cold cases in Kanagawa Prefecture, Japan.

Kusanagi Kei, a high-school student living with his aunt and uncle, has an encounter with a female alien. This alien is revealed to be a new teacher at his school. Later, he is forced to marry this alien to preserve her secrets. From there, various romantically-inclined problems crop up repeatedly.

Spurred by the flame raging in his heart, the Black Swordsman Guts continues his seemingly endless quest for revenge. Standing in his path are heinous outlaws, delusional evil spirits, and a devout child of god. Even as it chips away at his life, Guts continues to fight his enemies, who wield repulsive and inhumane power, with nary but his body and sword—his strength as a human.

Hibiki Tokai, a male third-class laborer from Taraak, ends up stuck on a battleship after a botched attempt at stealing a robot. When female pirates capture the Taraakian Vanguard, things don't look like they could get any worse.

Belle Lablac doesn’t really fit in as the only human being in a world full of anthropomorphic animals. No fangs, no fur, no scales, no claws. Lonely and eager to discover where she comes from, Belle journeys to find answers to the questions of her heart. Carrying nothing but her giant sword, the Runding, she faces a world of possibilities and pitfalls in hopes of discovering the truth.

In a devastated world overrun by monstrous bugs and ravaged by outlaws, there's only one person to call when you really need a job done right: Honoka. With a sixth sense for danger, sword skills second to none, and a smart-aleck A.I. tank by the name of Bogie, she's ready to tackle any job and solve any problem for her clients. But while crossing the desert one night, she finds a young man alone in the wasteland. It's the first step of a journey that will challenge even Honoka's amazing skills to their very limit!

Mamoru has a far-from-normal high school life with girlfriend Ayako, who possess magical powers.

Paris, 1742. While investigating the murder of his beautiful sister—Lia—D’Eon uncovers an evil which casts shadows in both the palaces of kings and the dark alleys of Europe. It is a dark and strange power—one which allows Lia’s soul to return from beyond and possess her brother in order to avenge her own death.