Starting out fresh, Mike puts some distance between himself and Marcellus, grieves over Grizz's transfer to New Orleans, and moves into a new house, where he meets his energetic new neighbor, Liz Garza, who turns out to be an ex-nun turned probation officer; Jamie Farrell, a young man with a troubled past who isn't quite what he seems, enlists Mike's help after he witnesses a quadruple murder and is pursued by the D.E.A. agents who committed the crime; Mike seeks out Marcellus for information, and is warned to steer clear; risking his career, Marcellus saves Mike and Jaime from certain death at the hand of the agents; faced with a serious illness, Marcellus reaches out for Mike's friendship.

On the anniversary of his brother Rick's death, Jamie decides to meet with his father, Richard Farrel, in an attempt at reconciliation and instead discovers his affair with a young woman named Cate Rawlings, who is later found murdered; at Jaime's request, Mike attempts to find out what evidence Marcellus has on the murder without revealing Richard's affair with Cate; after Jamie breaks into Cate's apartment to remove evidence implicating his father, he's arrested and unwittingly gives Marcellus the information he needs to charge Richard with the crime; even though Marcellus is angry that Mike deceived him about Richard, the former partners work together to uncover the evidence that clears Richard of the crime; Jaime is devastated when Richard rejects his efforts at reconciliation once his name is cleared.