Seeking evidence of the afterlife, Josh Gates enters an ancient Roman "Gate to Hell" that still claims victims. In New York, a medical doctor shows how consciousness survives death. In California, a medium shocks Josh with a message from beyond.

Josh talks with Dr. Deepak Chopra about reincarnation, explores a path to Islamic paradise, and faces a man possessed by an evil spirit.

Josh visits a tribe in Indonesia where people live with mummies, and a cryonics lab in Russia at the cutting edge of freezing humans for the future.

They say you only live once, but can we return from the abyss? In the Amazon, Josh meets a shaman who takes him on an ayahuasca trip to the brink of the Afterlife. And a team of investigators guide Josh into one of the most haunted places on earth.