Isagi Yoichi, a first-year forward, loses his chance for the Nationals because he has passed the ball to his fellow player in front of the goal. That's when he receives an invitation for Blue Lock. It's a facility to train one world's greatest striker out of 300 high-school-aged forwards so that Japan can win the World Cup.

Kira is eliminated from Blue Lock, and with that, the first day at the Blue Lock that promises to create the greatest center forward in the world begins in Isagi Yoichi 's life.