Because of Kuon’s betrayal, Team Z is faced with a desperate situation of playing 12-on-10, with the opponent knowing everything about their weapons and strategies. Even under such a circumstance, Team Z never gives up on the fight, and Isagi continues to believe in himself. Inspired by their passion, Chigiri runs through the field at an incredible speed, his weapon he has sealed away. His ego rocks the match when they are losing at 3-4.

The Z team has only one game left to play, and it will decide the future of its members. While everyone seems to be nervous about the kickoff, Isagi is trying to find a way to score goals without anyone's help.

The match continues to leave Team Z scared of Nagi's abilities. However, one of the members is not scared, even though they are facing a soccer genius...?

Each player unleashed their weapon and ego, and Team Z has caught up to a draw. They totally have the momentum of the game, but that has “awakened” Team V’s monster, Nagi. In the chain reaction to awakening, Isagi also learns to use his weapon and keeps fighting. The “heat” generated by the clashing of ego from both teams starts to affect Kuon as well.

Team Z launches a final counter to try and win against Team V. Isagi is trying to find the last piece he needs to crack the formula to become a goal machine.

With many dropouts, the "Blue Lock" project enters the second selection. A harsh second selection where former friends become rivals and former enemies become allies at a dizzying pace. There, Isagi meets Rin, the most powerful egoist ever, the younger brother of the genius Itoshi Sae, and the new Blue Lock ranking TOP ranker. Seeking further evolution, Isagi's fight advances to a new stage.

Isagi realizes that the conclusion of the match is in his and Naruhaya's hands. However, how will he go about beating Naruhaya? This will be a game that will not depend on genius players, but on "mediocre" players.

Barou joins Isagi and Nagi's team, already causing quite a stir with his conflicts with Nagi. Isagi is trying to see a way to mediate these two, which will be very complicated.

Isagi begins to realize that his former teammates made a great trio with Reo, making the best use of their own weapons. Now, he'll have to think about how he's going to get his much-desired "chemical reaction" with Nagi and Barou, if not, he won't be able to win. That said, the Barou remain not very cooperative...

By understanding and enhancing each other’s weapons, Isagi and Nagi are drawing countless paths to the goal. In contrast, with Chigiri, who has further evolved, at the center, Kunigami and Reo find themselves struggling to keep up, and a back-and-forth battle unfolds on the field. Meanwhile, Barou, who should have been the king of the field, was left behind in the evolutionary chain because of his overpowering ego. Having been robbed of the leading role on the field by Isagi, Barou finally falls to his knees.

Isagi and his friends barely manage to win as Barou awakens as the "villain" of the field. In order to cause a further "chemical reaction", they take away the only player who showed their ego to "eat" themselves and advance to the force stage. On the other hand, Bachira, who is looking for an opponent for the next match with TOP3, sees through the existence of a "Monster" in himself during training with Rin, and faces his own "ego".

Rin chooses to add Isagi to his team, and together with Bachira they pass the second selection. Waiting for them on the other side is a 5-on-5 match against a team of world-class players. Thanks to Isagi, Bachira, and Rin's coordinated play, they manage to score the first goal, but they soon find themselves overwhelmed by the opposing team's superior skill and ability. Despite this, they desperately keep fighting until the last second, unleashing their own "egos." As a result, the "Blue Lock" project, aiming to produce the world's greatest striker, enters a new phase.