Walter finally tells his family that he has been stricken with cancer. Meanwhile, the DEA believes Albuquerque has a new, big time player to worry about. Meanwhile, a worthy recipient is the target of a depressed Walter's anger, and Jesse makes a surprise visit to his parents home.

Walt and Jesse find themselves in close quarters with an unhinged Tuco. Marie and Hank comfort Skyler, who is distraught over Walt’s disappearance. Hank pays a visit to Mrs. Pinkman on some not-so-official business.

Walt attempts to reconnect with his family, while Jesse struggles to rebuild his life.

Despite ever-increasing tension between Walt and Skyler, he pulls out all the stops in an effort to reconcile with the family. Elsewhere, Saul is instrumental in getting Jesse involved in a most-unusual investment opportunity.