With acting boss Jackie Aprile dying of cancer, Tony prepares for a power struggle with Uncle Junior. Christopher and his associate Brendan make trouble for themselves when they jack a truck full of DVD players. Tony's mother Livia finally agrees to live in a retirement community. Big Pussy and Paulie Walnuts are sent to find a stolen car.

During a trip to Maine for Meadow's college interviews, Tony sees a man he believes is a relocated mob snitch. Back at home, Carmela receives comfort from Father Phil.

Uncle Junior enjoys a romantic tryst in Boca with his girlfriend Bobbi, not realizing that she's been gabbing to her beauty-parlor friends about his oral talents. Meanwhile, controversy arises when Meadow's soccer coach announces he's leaving the school.

Hit men are sent out to whack Tony, who comes out of his depression when he meets Isabella, an Italian exchange student staying next door.

Season Two opens with the aftermath of the federal crackdown: Junior's in jail, Melfi refuses to see Tony, Christopher's expanding into new business ventures, Pussy is still missing...and Tony's adjusting to life as the new boss. To complicate matters even more, Tony's free-spirited sister Janice arrives to take care of Livia.

Back in Jersey, Furio soon lives up to his name by unleashing his fury on the delinquent proprietor of a local 'tanning salon.' Dr. Melfi shares her guilt over dumping Tony as a client during a session with her own therapist. Meanwhile, Tony learns from Hesh that his father had emotional secrets of his own.

Although Richie is miffed at Tony for forcing him to build a ramp for the pizza-parlor owner he paralyzed, he decides to make a peace offering. Unhappy with their lowly status as Christopher's lackeys, Sean and Matt decide to pledge their allegiance to Richie--through a violent, unexpected act.

Richie meets with Tony to complain about his end of the garbage business, then meets with Junior to complain about Tony. Later, Tony orchestrates the 'planned bankruptcy' of David Scatino's sporting-goods store while Scatino's wife introduces Carmela to her handsome widowed brother.

In the Season Two finale, Tony has a series of 'fever dreams' that help to shed light on some of his problems--particularly his troubles over Big Pussy.

Tony's concerns that his mother will rat him out to the feds expire when she, literally, does. Later, Janice arrives to arrange the funeral, which takes a bizarre turn.

Dr. Melfi's attempts to steer Tony into behavior-modification therapy take a detour when a personal crisis gets in the way. Meanwhile, Ralph Cifaretto finds a way to endear himself to Jackie Jr.--but not to Tony.

Tony convinces Uncle Junior to seek a second opinion for his cancer treatment. Meanwhile, Carmela debates whether or not to take Dr. Melfi's advice and see a shrink, Big Pussy's wife Angie regrets asking Carmela for some money to help her sick dog, and Christopher continues to endure a humiliating probation period at the hands of kinky Paulie.