S.H.I.E.L.D. puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.

Fitz and the team enlist the aid of an Asgardian to unlock the secrets of the ancient Monolith that swallowed Simmons, and Agent May is at a crossroads in her personal and professional life.

Daisy, Mack and Coulson race to protect Lincoln as Rosalind’s team hunts down the Inhuman in their quest for powered people. Meanwhile, Hunter proves that there is no line that he will not cross to exact his revenge against Ward and HYDRA.

Coulson and the team search for the Inhuman who is killing other Inhumans. Meanwhile, May feels that Hunter's mission to take down Ward is getting too personal.

The stakes get even higher as Hunter and May continue to go after Ward and HYDRA, and Daisy and Coulson begin to suspect that the ATCU may be keeping a big secret from S.H.I.E.L.D.