When a new Inhuman is discovered, Coulson and the team have an encounter with another organization seeking powered people; Fitz goes to extreme measures to determine how to get Simmons back.

In the aftermath of his trip to Maveth, Coulson is more determined than ever to get to Gideon Malick and put an end to HYDRA once and for all. Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D.?

Bobbi and Hunter become ensnared in an assassination plot after tracking Malick to Russia. As S.H.I.E.L.D. races to save the lives on the line, the team is changed forever.