With Colonel Glenn Talbot now on their trail, Coulson and his team seek refuge in the last place anyone would look, where they begin to uncover S.H.I.E.L.D.'s most dangerous secrets. Secrets that could destroy them all.

Just when there's no one left to trust, Agent Maria Hill returns to team up with Coulson as S.H.I.E.L.D. is being destroyed around them.

Coulson and his team are now wanted fugitives with limited resources, but that's not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?

Hunted and running out of solutions, Phil Coulson puts his team right in the line of fire in the hopes of saving them all. But with General Glenn Talbot, HYDRA, and Carl Creel all on the attack, can they possibly survive? Meanwhile, a mysterious Doctor harbors some dangerous secrets that could destroy one of our core team members.

While on a mission to learn more about the secrets of the mysterious writing, Coulson finds himself attacked by the only person he can trust: Agent Melinda May. Meanwhile, the rest of the team is trapped in an explosive situation, and it's up to Fitz to save them--but is he up to it?

The world turns against S.H.I.E.L.D. when HYDRA impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.

Coulson's team must deal with the consequences of their war with HYDRA as shocking revelations threaten to tear them apart, and HYDRA makes a dangerous move that may involve a traitor in S.H.I.E.L.D.'s midst.

Coulson and his team are still reeling from a shocking revelation that leaves the team fractured as they must decide what to do with one of their own. Meanwhile, Bobbi and Mack reveal their true allegiance to Hunter, while elsewhere, Ward and Agent 33 embark on a personal mission.

Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.

The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.

With only two episodes left before S.H.I.E.L.D. loses one of their own, Daisy's prophecy ticks closer towards a major loss, as the aftermath of the events of Captain America: Civil War force S.H.I.E.L.D. to register the Inhumans.

It's a showdown a season in the making as S.H.I.E.L.D. takes on Hive, and when his master plan is finally revealed, the team must spring into action. Who will live and who will die?

Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.

May works to uncover the truth about what happened to her; Aida's next move puts everyone's life at risk.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.

With the surprising emergence of Ghost Rider, Coulson and the team attempt to stop Aida from ending the world.

Coulson uncovers General Hale's true agenda, and it could be the end of the world if S.H.I.E.L.D. doesn't help her.

Coulson is forced to team up with surprising allies to save the world, while the S.H.I.E.L.D. team attempts to track down and rescue him.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

The team must find a way to stop Ruby before the prophesied chain reaction that can destroy the Earth is put into motion.

Coulson and the team find themselves under siege at the Lighthouse.

A newly determined Talbot takes Coulson to meet the enemy and attempts to avert Earth's destruction.

Daisy's future as the Destroyer of Worlds could take a critical change.

Coulson's life or death is the challenge the team finds themselves in, as the wrong decision will cause the Destruction of Earth.