The case of a schizophrenic mom with a deadly disease and her teenage son who have traded caretaking roles holds a special interest for Dr. House.

A baseball player's comeback is cut short when he breaks his arm and House and his team have to act fast to figure out what is causing major bone loss that's killing the player and his dreams.

Dr. House and his team race to diagnose a member of the mob and get him well enough to testify and enter the witness protection program while Cuddy works to convince Vogler of House's importance to the hospital.

House is faced with a problem he may not be able to solve and Stacy returns.

A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.