When Alex's younger brother, Aaron, shows up at Seattle Grace-Mercy West with a hernia, it's up to Alex to get Bailey's approval for his pro bono surgery. Matters are further complicated when Aaron discloses that his family has not heard from Alex since he arrived in Seattle, and parts of Alex's past long kept secret are revealed to his friends and fellow doctors.

A gunman opens fire at a local college, sending mass casualties to the hospital; Arizona's return is not warmly received.

Meredith must choose between her fertility treatments and her eyesight when she begins having trouble seeing, Mark makes it clear to Callie and Arizona that he takes his role as father-to-be very seriously, and April discovers there's more to Dr. Stark than first appears.

Owen stresses teamwork and moves his leadership role over to the baseball field when he signs the doctors up for a baseball league, pitting them against their biggest competition, Seattle Presbyterian; Lexie tries to hide her jealous rage when she sees Mark with a new woman, but her emotions get the better of her; Alex fights to keep Zola at Seattle Grace after it is suggested that she be moved to another hospital due to a conflict of interest with Meredith and Derek; and Richard scolds Meredith and Bailey for their feud

The survivors from the crash are asked to make an almost impossible decision that will affect the rest of their lives. Meanwhile, tension grows between Jackson and April after they're forced to work together, and Alex tries to restrain himself with one of the interns.

Ben worries that a casual conversation with Derek could potentially cause issues for Bailey, Cristina turns to Shane as tension grows with Meredith, and April's upcoming wedding makes for an uncomfortable situation between Jackson and Stephanie. Meanwhile, Meredith plans a Thanksgiving dinner at her house.

As Derek prepares for his move to DC, Meredith keeps herself busy at the hospital. Meanwhile, Jackson and April deal with difficult news, and Arizona and Amelia discuss how to best approach Dr. Herman.

The pressure is on as a determined Bailey tackles her first day as Chief; meanwhile, April's marriage is in jeopardy and she finds herself unable to address her problems; Meredith struggles to juggle all her responsibilities and Amelia works to define her relationship with Owen.

In the midst of the sisters’ dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona nervously waits to find out more about Callie’s new girlfriend.

Stephanie’s relationship with Kyle becomes complicated. Meanwhile, Meredith encourages Amelia and Owen to take a chance and choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.

Meredith and Maggie support Amelia on an important day; Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.

When one of Grey Sloan’s own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

A difficult surgery brings back pivotal memories for Meredith, Richard, Owen and Stephanie, as they work together to save a life.

The doctors’ lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point.

Meredith and the team are focused on helping Owen’s sister after her shocking return, and Amelia faces a conflict over a patient. Meanwhile, Bailey is forced to give Grey Sloan a facelift after the fire, and the doctors are introduced to a few new faces that spice things up around the hospital.

After a roller coaster car falls off the track at the county fair, the doctors at Grey Sloan tend to patients who spark memories about ghosts from their past. The series 300th episode!

Meredith Grey and the team of doctors at Grey Sloan Memorial are faced with life-or-death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.

The doctors at Grey Sloan Memorial vie for a new position. Meredith is seemingly distracted and struggles to stay focused, and Maggie finds herself the keeper of a big secret while Amelia and Owen try to figure out their relationship. Meanwhile, Jo and Alex's honeymoon doesn't go exactly as planned.

A patient gives Meredith some clarity on her dating situation around the holidays. The strain on Bailey and Ben’s marriage comes to a head. Meanwhile, Betty drops a bomb on Owen and Amelia.

When a trauma patient arrives at Grey Sloan, it forces Jo to confront her past. Meanwhile, Bailey and Ben have to talk to Tuck about dating.

As fog begins to cover Seattle, the doctors of Grey Sloan navigate through personal complications. Meredith and Alex attempt to save Gus, while Levi talks some sense into a struggling Nico.

Meredith, Richard and Alex must deal with the consequences after Bailey fires them from Grey Sloan for insurance fraud. After disappearing in the fog, Jackson helps a man in a dangerous situation, as his relationship with Maggie comes to a new crossroad. Meanwhile, Tom gets new responsibilities at the hospital that throw the doctors for a loop.

Meredith faces the medical board as her future as a doctor remains uncertain, and she’s forced to reckon with her past in some challenging ways. Meanwhile, the interns are put to the test as they are each vying to be the most successful on their respective cases in the absence of some of the attendings.

Jo becomes a safe haven volunteer and gets a call that a baby has been dropped off at Station 19. Meanwhile, Meredith moves forward with her life after facing the medical board. Jackson takes a big step in his budding romance with Vic, while Bailey and Amelia swap pregnancy updates.

Richard finds out Maggie quit Grey Sloan and is concerned about how she’s handling the death of her patient who was her estranged cousin. Bailey returns to work after taking some personal time off, although Koracick doesn’t make her first day as easy as she’d like. Meanwhile, Meredith thinks she might miss DeLuca, and Amelia has an update for Link on her pregnancy.

Jackson creates an uncomfortable situation when he invites new girlfriend, Vic, to what he thinks is Richard and Catherine’s anniversary celebration, only to discover the dinner was called for different reasons. Elsewhere, Levi brings Nico on a trip to visit an ailing family member.

DeLuca can’t figure out what’s going on with his incurable patient Suzanne and he turns to a diagnostics genius, Dr. Riley from UCSF, for help. Bailey checks in on Joey, a foster kid that Ben brought into Grey Sloan. Meanwhile, Amelia is getting the results of her paternity test and Jo confronts her about how she is treating Link.

DeLuca is irritated after Meredith takes over his patient Suzanne whose symptoms continue to stump the doctors at Grey Sloan. Elsewhere in the hospital, Jackson, Owen and Jo work on a couple injured in a bear attack; and Levi is hurt when Nico doesn’t want him to meet his parents.

Bailey and Ben face a huge, life-altering decision, while Meredith and several of the doctors reflect on the past.

A wealthy inventor arrives at Grey Sloan and asks Koracick for help, while Meredith struggles to save a woman with diabetes who has been rationing her insulin. Jo and Link fight to save a young man who fell onto train tracks, and Jackson and Vic's relationship hits a snag.

Meredith heads up a pro bono surgery day, but the overwhelming patient response causes her to struggle to keep things in order. DeLuca treats a teenage patient whom he suspects is in danger and desperately tries to get Bailey to support his theory.

Richard preps to present his PATH pen at the LA Surgical Innovation Conference but becomes distracted by his issues with Catherine. Maggie and Teddy run into people from their past at the same conference, while Hayes relives moments from when he met his late wife.

Owen and Link treat an older woman who wakes up from surgery and can’t stop singing, while Teddy helps Koracick stay afloat after an estranged loved one from his past comes to the hospital looking for help. Meredith, Bailey and Maggie focus their efforts on a difficult patient with a tricky diagnosis.

The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic; an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment.

Bailey finds herself in the middle of an argument with patients' families as they await news about their children who were injured in a fire; Winston surprises Maggie; Amelia and Link try to have some fun as new parents.

As traumas and pressure mount, Grey Sloan doctors try to find a path forward, and Richard questions his faith. Meanwhile, Maggie gives Winston hospital privileges and they work together to treat an uneasy patient. Jo, Link and Jackson play an unconventional drinking game.

Jackson pays a visit to his father that helps set him on the right path.

As the city of Seattle revels at the Phoenix Fair celebrating the city’s rebirth post-COVID, the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she’s having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother‘s past.

The crossover starts on Station 19 S05E01 Phoenix from the Flame (I).

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

A former patient of Link’s, Simon, is in the ER with his pregnant wife; and Bailey receives an offer from Nick.

The blood shortage at Grey Sloan Memorial continues. Meanwhile, Meredith makes a risky decision regarding a patient, and Owen’s actions to help his fellow veterans come to light.

After a long six months, Grey Sloan Memorial has reinstated its residency program. A group of talented and striving young interns has been recruited as the attending surgeons work to rebuild the program to its former glory. Meredith, still functioning as the interim chief, sees Nick for the first time since she rejected his offer to move to Minnesota. Meanwhile, Bailey tells Richard she is not ready to return to work; Levi works up the courage to break disappointing news to Jo, and things turn awkward when Link realizes he has met one of the interns already. With Amelia and Maggie’s help, the new doctors are thrown into their first day on the job dealing with injuries from a recent tornado.

It’s Meredith’s last day at Grey Sloan Memorial and the doctors plan a goodbye surprise, while Nick confronts her about the future of their relationship. Elsewhere, the interns compete to scrub in on Maggie and Winston’s groundbreaking partial heart transplant procedure, and Richard asks Teddy an important question.

The attending surgeons fly to Boston, forcing a reunion between Nick and Meredith. Bailey gets a big surprise.

Meredith and Amelia work to secure funds for their research while Amelia finds herself at odds with a new attending. Levi runs into someone from his past, and Owen gives Winston advice. Lucas ditches Mika, forcing her to treat a patient alone.

It's all hands on deck at Grey Sloan when a group of medical students is injured by a floor collapsing at their white coat party. Jo and Link are forced to talk about the future, while Jules confronts Winston about his attitude.

An unexpectedly complex case brings back painful memories for Simone. Jules and Blue make a high-stakes bet on who can finish their procedure log first. Richard suspects Winston is avoiding him.

Wildfires threaten the Seattle region, leading to a flood of patients and emergency procedures. The doctors juggle overcapacity in the ER, complex surgeries and personal stress. Meanwhile, Meredith makes a rash decision that can't be undone.