The attending surgeons and interns work together to solve a medical mystery when a college kid comes in with what first looks like food poisoning but has escalating and dire complications. Meanwhile, Jo spends her day off with Bailey.

Bailey recruits the interns to create a series of social media videos informing teens about sexual health. The videos, filmed at Grey Sloan in front of a group of high schoolers, hit home as a student has medical complications during her visit. Elsewhere, Meredith and Maggie learn something new about Zola.

Simone's wedding day arrives as Jo and Link's relationship hits a major turning point.

An unexpectedly complex case brings back painful memories for Simone. Jules and Blue make a high-stakes bet on who can finish their procedure log first. Richard suspects Winston is avoiding him.