When famous surgeon Dr. Harper Avery is rushed to Seattle Grace-Mercy West, the staff is surprised to discover that one of their own is related to this legend, and his unorthodox request for his surgery causes tensions t between Derek and Richard. Meanwhile Callie and Arizona try to help Teddy and Sloan move on from their pasts and find greener pastures.

Den berømte Dr. Harper Avery kommer til Grey Sloan, og hos Bailey er nervene er på høykant. Samtidig dukker et kjent ansikt fra Merediths fortid opp, og Amelia prøver å holde på en hemmelighet.