The fifth season ends with Howard and Bernadette deciding to get married before his NASA mission, causing the gang to scurry into overdrive in an effort to stage the wedding. NASA astronaut Mike Massimino has a cameo as himself.

With his friends on dates, Raj must face his loneliness. Also, Wolowitz is caught in an argument between Bernadette and his mom, even while he’s in space.

When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. Meanwhile, in space, the other astronauts pick on Howard.

Amy feels threatened when Sheldon hires a young female assistant, and the pressure of being in space takes its toll on Wolowitz.

When Wolowitz returns from space, he doesn’t get the hero’s welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.