建筑工地一个工人高空坠落身亡，G认为是电击谋杀案，但尸体上却没有电击痕迹，进一步尸检表明受害者血液中铁含量超标，死者本身就是一个导电体，电钻接地线被破坏，同时死者橡胶鞋底被钉入钉子，三者共同作用造成电击死亡却无痕迹现象。钉子上指纹及接地线界断面证明是前工会代表做的案子，此人事前曾试图误导G怀疑工地经理因死者提倡罢工而谋杀他。一个少年死在自己医生的家里，有极端行为紊乱病，CSI检查死者衣物发现内裤上粘有纤维，而外衣上没有，对女医生家的地毯检验表明死者曾仅着内裤被包裹在毯子里，进一步询问表明女医生和他妈妈用荒诞的“重生”疗法，将孩子包裹在毯子里模仿母亲阴道生产推搡挤压时意外撞击后脑致死。

As the CSI's continue their search for and discover the identity of the "Miniature Killer", Grissom and Sara's relationship gets exposed to the rest of the team as she goes missing during the investigation. The "Miniature Killer" is finally captured, but not before a member of CSI becomes the killer's final victim.