With the help of an out-of-this-world remote control, Stewie and Brian travel through alternate universes, including a post-apocalyptic world and a parallel world run by dogs where humans are pets.

When Lois finds a lump on her breast, she goes to the doctor to test for cancer. The tests come back benign, but the doctor looks at her family medical history and reveals some news about Lois' heritage.

Chevy Chase and Dan Aykroyd move to Quahog. Brian and Stewie find out about their secret agency. They are told that there are Russian Sleeper Cells all over US. They go talk to Mayor West, and find out he is one of the sleeper cells. They follow Mayor West to Russia where they disable a nuke aimed at the US.

When Brian begins dating an older woman, the family begins to make fun of him. After Brian's new fling breaks her hip, he gets the pleasure of becoming her errand boy.

After attending to the concert of a teen superstar, Stewie discovers a surprising secret about the singer. Meanwhile back at home, Chris tries to prove the existence of the Evil Monkey.

Father doesn't know best when Quagmire assumes responsibility for a baby left at his doorstep. Meanwhile, Stewie creates a stupid clone of himself that he uses as a slave. When he ends up creating a clone for Brian too, they find out that the clones are unstable, at which point the clones break down.

Peter and the guys interview potential friends to fill the vacancy left by Cleveland. Meanwhile, Brian discovers that Quagmire hates him.

When Brian accidentally kills another dog, he is surprised to see that no one cares, so he tries to convince everyone that the life of a dog should have the same value as a human one. Meanwhile, Lois hires a maid who doesn’t listen to Peter

When Peter gives Lois’ dad the bachelor party he never had, Mr. Pewterschmidt goes into a coma. Even Dr. House can't help. Lois gains control of Pewterschmidt Industries which she passes to Peter. He gets power-hungry and fires the board. Mr. Pewterschmidt bounces back and tries to regain control of what he’s built.

When Peter hits his head and suffers amnesia after getting in a fight with Richard Dawson on Family Feud, he forgets everything about his life, including his family and friends. In an attempt to try to bring back his memory, Lois decides to reintroduce Peter to his old self, until he begins to hit on other women, much to Lois's dismay. She decides to take the kids and leave Peter, giving Quagmire the opportunity to score with Lois. Peter now must prove to Lois he can remember her and make himself worthy of her again.

Brian gets a gig writing for a teen magazine about the average American girl, but when he starts trailing Meg for research he discovers that her desperate attempts at dating have led her to a guy in the slammer. When Brian tries to expose Meg’s secret to the family, he finds out that her boyfriend, Luke, has broken out of jail and has been hiding in the Griffin’s house.

When Chris and Stewie go missing for several days, Lois is at her wit's end until she sees a psychic who assures her they are safe. Even after the boys return home, Lois and Peter's psychic obsession continues, and Peter takes it a step too far when he starts charging neighbors for his extrasensory perception. Meanwhile, Chris develops a crush on a girl at school.

Stewie cross-dresses in order to star in the American version of Jolly Farm Revue. Meanwhile, Peter makes Lois feel bad about her age.

After Peter has some luck selling footage of a celebrity he caught off-guard, he decides to become a full-time paparazzo. To make matters worse, his new boss, Angela, finds him irresistible and plagues him with unwanted advances. When Peter rebuffs her, he winds up getting the ax. Meanwhile, Stewie makes his theatrical debut in a school play, only to be overcome with stage fright.

Lois encourages Brian to submit his pilot script to a network. James Woods gets involved and things don't exactly go according to Brian's original plan. Meanwhile, Stewie has a bit of a mishap.

When the local news announces that the Earth will be destroyed by a black hole in 24 hours, everyone in Quahog goes nuts trying to live out their last day.

In the 150th episode, Brian & Stewie get locked in a bank vault, they are forced to deal with each other on a whole new level.

Unlike any other FAMILY GUY episode, the acts will play out in real time as Brian and Stewie react to being locked in a small space with no baby food or martinis to keep them from losing their minds while they hatch an escape plan.

Quagmire can accept his dad's lifestyle choices, but not when they involve Brian.

Peter, Joe, and Quagmire search for the source of a dirty joke.

Peter makes good on another power outage at home--by entertaining his family with a retelling of Star Wars Episode V: The Empire Strikes Back. Newcomers to the story include Mort as Lando Calrissian, Chris' boss Carl as Yoda, and the Giant Chicken as the nefarious Boba Fett.

With her vision waning, Lois elects to get LASIK surgery, but exploits her new disability for monetary gain. Meanwhile, Peter, Chris and Stewie must partake in all the activities with Doug that his father neglects.

While at an old record store, Peter and the guys recount tales of three rock legends: Jim Morrison, Muddy Waters and Elton John.

Quagmire meets an avid dog lover, and pretends Brian is his dog in an attempt to win her over. Meanwhile, Chris helps Stewie track down the culprit who stole his Halloween candy.

Impelled by nostalgia, Peter recreates movie scenes from his favorite decade; Stewie and Doug compete to retrieve a Frisbee stuck at the top of the jungle gym.

When Peter and Quagmire accidentally switch underwear, they begin to mimic the other's behavior. Stewie and Doug agree to commit each other's murders.

Stewie takes drastic measures when he thinks he is diagnosed with terminal cooties. Peter becomes infatuated with Bonnie's cooking.

Lois and her father attend the funeral of Lois' childhood nanny. Peter and the rest of the family turn Pewterschmidt mansion into a hotel.

A new boss quells Peter’s favorite part about work: office birthdays. Stewie is put in detention and comes out a ruffian.

In noir-style, Peter/Mac investigates the disappearance of Meg/Sister Megan.

After a Christmas tree lightning ceremony Brian crashes into Mayor West's nativity scene causing outrage.

An accident leaves Peter with a high-pitched voice, so Jesus coaches him into fending off the choir boys; Stewie is attracted to Lois' new masculine physique.

At odds with Peter, Lois takes Quagmire to her high school reunion; the rest of the family must cover up the death of a pizza delivery man.

Peter hires the town's new lawyer, Brick Baker, to represent him in litigation against his new neighbor -- who turns out to be Brick; Brian and Stewie become lobstermen and save Rupert from the perils of the deep.

The Griffins tell their own versions of three HBO shows: "Game of Thrones," "Succession" and "Big Little Lies."

Meg is invigorated by her new role as a getaway driver. Meanwhile, Quagmire can't rid himself of the hiccups and implores Peter to kill him.

After Brian sustains an injury, Lois gets hooked on his painkillers. Meanwhile, Cleveland refurbishes Peter's ping pong table, which becomes the hot spot in the neighborhood.

When Lois' piano student, Alana, comes to work for the Griffins, Lois is initially glad for the help, until she realizes Alana's intentions are more sinister than she thought.

Peter and Chris take a road trip to Canada to prove the existence of Chris' girlfriend. Meanwhile, Lois and Meg compete for the attention of a handsome handyman.

The guys' physical prowess is tested at Mayor West's dude ranch. Meanwhile, Stewie thinks he's gotten his first period.

Peter attends a business conference in Atlantic City with Preston. Meanwhile, Stewie helps Chris prepare for his role in Adam West High's rendition of "Romeo and Juliet".

Meg agrees to be Bruce and Jeffery’s surrogate causing a pregnant Meg to annoy her family. But, when the couple fails to pick up the baby, the Griffins must take care of their new family.