When a judge is murdered in Griffith Park, Brenda's investigation takes an unexpected twist. Her best witness, or perhaps her prime suspect, is his teenaged son with autism. Challenged by the boy's behaviors, but convinced he has the clue to unraveling the case, Brenda must try to understand his disability, and thereby learn what he knows. Meanwhile, she must keep his mother, and the child protective system from taking custody of the boy, limiting her access to him, and the killer.

Brenda finds herself at odds with the FBI in a struggle to gain control of the murder investigation of a well-known businessman. Deciding to work in tandem, Brenda finds herself working directly with Fritz, who was assigned to the case. After discovering that the FBI has ulterior motives in the investigation, Brenda's relationship with Fritz is put under further strain.

Things are not as they seem when Brenda and the team investigate the accidental murders of three college students caught in the middle of a gang shootout. Brenda must also continue her attempts at keeping her relationship with Fritz under wraps while her mother remains in town.

Brenda and the team find themselves wading through a long list of suspects when a celebrity photographer takes a fatal fall from his hotel room balcony. Once the cause of death is determined, the motive points to a big time actor with something to hide. In the meantime, Brenda starts to feel like Fritz is behaving strangely, making her realize that superstars may not be the only ones who have secrets to keep.

Leaving the scene of an accident to get to a multiple homicide scene, Brenda finds herself unable to drive the streets of L.A. which she worked so hard to learn. Once she gets to the crime scene, she and the PHD are faced with another challenge: the murdered bodies are nowhere to be found. In order to solve this case, they must first search for the victims before they can hunt for the killer.

Resulting from the showdown in the murder room, Brenda finds herself taking some involuntary time off. When she is asked to help a friend solve a murder that is linked to a terrorist group, Brenda works to find the killer and still keep it under wraps. Meanwhile, Commander Taylor jumps at the chance to break apart the PHD while Brenda is away.

The body of a long-dead murder victim is uncovered along with Lt. Provenza’s business card, setting off the squad’s search for his identity and killer. When the bullet is traced to a gang weapon that had been turned into the LAPD 15 years prior, Deputy Chief Johnson is forced to contend with political activist Father Jack.

In an effort to get good PR for the department, Deputy Chief Johnson takes a journalist on a ride-along, but when the Crown Vic is targeted and shot at, Brenda is forced to live under 24-hour police protection, while being the key witness in the case she must solve.

Brenda and the team must determine if a murder was revenge or mere coincidence when a recently released murderer turns up dead, the victim of a hit-and-run. As usual, Brenda's personal life isn't much better: she must deal with a recently incapacitated Fritz.

Det. Julio Sanchez' little brother Oscar is shot and killed, leaving Julio beside himself with grief and seeking his killer any way he can, which threatens the investigation.

When an adolescent boy is found murdered where members of the Tres Colores gang frequently spend time, the subsequent murders of two more gang members point Brenda and the team to gang warfare. Unfortunately, the evidence trail leads them in a different direction.

One of Brenda's detectives is ambushed on the street, and the main clue to figuring out the motive behind the attack is a garbage bag containing more than $37,500. The investigation then turns into a race to clear the detective's name over allegations of witness tampering.