As Sykes begins his end game, the agents discover that Helena is still alive... and teaching high school literature. Meanwhile, Jane reveals the full extent of her plan but one agent will lose their life carrying it out.

With the fate of the world in their hands, Pete and Myka's only hope of finding a cure to the Sweating Sickness is a drunken history professor. Meanwhile, Steven and Claudia enter Artie's subconscious in an attempt to bring him out of his coma before he fades away for good.