16 year old Joan Girardi is approached by someone claiming to be God. He gives her a mission, get a job. Will Girardi, Joan's dad and new chief of police for Arcadia, is trying to solve the case of a serial killer.

God encourages Joan to learn how to play chess; Will must work with a psychic on a missing toddler case; Helen hopes a miracle will enable Kevin to walk again.

Joan baby-sits for a 6-year-old boy who is obsessed with death; officers assault a black man at a gas station.

God's mysterious ways once again bewilder Joan, when He asks her to volunteer at the high-school art show, so that she can keep Adam Rove's sculpture from being exhibited. Elsewhere, Will feels pressure from the DA's office to call a man a hero after he shoots and kills a home intruder. Meanwhile, Kevin grows weary of receiving special treatment because he uses a wheelchair.

When the hospitalized Joan is diagnosed with Lyme disease, she begins to question if she's been seeing God or merely experiencing the hallucinations that can be symptomatic of her condition...

Upon hearing that Joan may have been suffering from the symptoms of Lyme Disease for months, a somewhat relieved Will and Helen believe this news may explain Joan's mood swings and atypical behavior, while a concerned Adam wonders if Joan will be different upon her recovery. Meanwhile, the hospitalized Joan experiences a crisis of faith -- and considers revealing to someone close to her that she's been talking to God. In separate circumstances, Helen and Will begin to rethink their belief systems after, respectively, experiencing spiritual dreams and miraculous events.

After a summer of therapy and with school resuming Joan tries to return to a ""normal"" life even as she ignores God, who keeps reappearing; Will is sued for emotional distress by Andy Baker, whose drunk driving caused the accident that paralyzed Kevin; Luke and Grace try to adjust to their relationship.

Joan prepares to prosecute a case for a mock trial at school, per God's request, while enthusiastically planning a way to celebrate her one-year anniversary with Adam, who has secretly betrayed her.

Joan surprises everyone with her passion in prosecuting a mock case against the equally motivated defense attorney, Grace. Meanwhile, while trying to hide his guilt from Joan as she plans a special anniversary night out with him, Adam decides to confess his wrongdoing to an appalled Grace.

Meanwhile, Will investigates the murder of an eight-year-old girl and Helen continues her study of catholicism.

In the wake of Joan’s breakup with Adam, God tells her to do some house cleaning, which puts her in the middle of a school scandal.

God tells Joan that the last two years were a spiritual boot camp for her greatest challenge yet, pitting her against a man with a sinister agenda.