Wonder Woman returns to Paradise Island to make up with her mother for her rapid departure, only to find the Amazons transformed to statutes. The sorcerer Felix Faust is holding them hostage to force Diana to recover three ancient artifacts.

Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own choice. However, this gang proves short-lived as its major weakness proves no match for Batman's wiles.

The Justice Lords, an alternate version of the League from a different dimension, capture their counterparts and plan to bring their own brand of justice to the new Earth.

After Superman makes the ultimate sacrifice to save his fellow heroes, the Justice League and rest of the grieving planet must learn to live in a world without Superman.