Megan Donner returns to the CSI unit in time to work on a jet crash in the Everglades. While searching for survivors, they inexplicably discover a female victim found five miles from the crash site. When the only survivor says the woman opened the plane's hatch in order to commit suicide, Horatio is suspicious. The team must now recreate what happened on that fatal flight, especially when the pieces don't quite fit together.

The team investigates the death of a young model, whose body was found near a juvenile detention camp for girls. Across town, Delko and Speedle probe the bizarre death of a man who was apparently burned from the inside.