Megan Donner returns to the CSI unit in time to work on a jet crash in the Everglades. While searching for survivors, they inexplicably discover a female victim found five miles from the crash site. When the only survivor says the woman opened the plane's hatch in order to commit suicide, Horatio is suspicious. The team must now recreate what happened on that fatal flight, especially when the pieces don't quite fit together.

An arm in a shark's gullet and a girl who was shot at sea lead the team to a smuggler who was running Cuban refugees and cocaine in a foundering ship.

During a typical morning rush hour in downtown Miami, an unseen sniper chooses three victims at random and opens fire, killing each with a single shot to the head. Horatio and his crew rush to the scene, which is quickly mobbed by TV news reporters eager to spin the murders into a national story. The initial investigation doesn't reveal much, as there were no witnesses and little evidence remains. But the case heats up when the sniper strikes again, killing two more innocent people.