The Winchesters are called regarding a robbery of their father's storage unit, and track down the robbers to find the item stolen is a cursed rabbit's foot, which provides great luck until lost, and once lost the previous owner dies within a week.

Bela gets in the way yet again as Sam and Dean are investigating multiple victims who drowned even though they were nowhere near water. Sam and Dean make the creepy discovery that the victims all saw a ghost ship right before dying. They tell Bela to stay away, but she's not so willing to leave, as someone's paying her a lot to solve the same case Sam and Dean are investigating.

The brothers capture a female vampire named Lucy who has no idea how she became one, which leads them to Dixon, a male vampire who is a little too giving. Gordon returns with a vengeance leaving Sam in danger.

Dean interrogates a college student after the death of Dr. Greggs. Bobby, Sam and Dean all discover the truth behind the fatal death when they all get locked in a nightmare of their own.

FBI Agent Henricksen finally captures Sam and Dean, but is caught in the middle when a horde of demons descends on the small-town jail to eliminate the brothers.

Sam and Dean discover a doctor who, back in 1816, became obsessed with finding the secret of eternal life by taking people's vital organs. Meanwhile, Bobby finds Bela and Dean leaves Sam to confront her.