After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.

Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andy’s family was visited by the Demon, Sam wonders if he could be one of the special children.

Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.

Sam contacts Dean after being missing for a week. When they reunite, Dean finds Sam covered in blood and with no recollection of what happened.

Hunter Rufus Turner calls in Bobby, Sam, and Dean to deal with a demon infestation in his town, but they soon discover the truth is much more horrifying. Meanwhile, Castiel goes to seek the only entity that can defeat Lucifer.

Sam, Dean and Castiel track down the Colt and head off to find Lucifer to send him back to Hell. It’s a hunters’ reunion when the crew joins forces with Bobby, Ellen and Jo for what could be their last night on Earth.

Sam and Dean investigate a string of gruesome murders and discover the Egyptian god Osiris is behind the deaths. The vengeful god is putting people on trial for their past mistakes and killing them if found guilty. Osiris hones in on Dean’s guilt and decides he’s the next to stand trial. Sam steps in as Dean’s lawyer, but both brothers are unprepared when Osiris calls an unexpected witness Jo.