The Ghostbusters happily journey to Paris for the unveiling of their statues in Madame Tutu's Wax Museum. During their visit they have to stop the Tooth Scaries from bringing evil statues to life and prevent the Eiffel Tower from being destroyed.

Big Evil returns to Hauntquarters and curses Prime Evil with the Arcane Curse, a spell that can only be broken by performing a geniune heartfelt good deed. A battle between Prime Evil and Big Evil takes place at Ghost Command with no winner in sight for the Ghostbusters.

When the other-dimensional Invertroids begin capturing people through mirrors the Ghostbusters join forces with Jessica's uncle John Guardian in order to defeat them. But for the Ghostbusters to prevail a great sacrifice has to be made.

The Ghostbusters travel to the future to help Futura save her nephew, Laser and his friends Rae and Tempo who have been captured by Corpulon, a large slug-like energy ghost who seeks vengeance against Futura.

The Ghostbusters travel to Norway to guard peace prize winner Dr. Alex Miller and Jessica from Prime Evil's latest ghostly plan. The gang not only has to protect Dr. Miller from Apparitia and Scared Stiff, but also stop the runaway train they find themselves on.

The Ghostbusters go back in time to ancient Rome to aid Madam Why's great ancestor , Tonya and prevent Prime Evil's ghosts from stealing a magical wreath owned by Julius Ceasar. It is not long before the Ghostbusters are taking part in a deadly chariot race against Marcus Phantamus.

Prime Evil's latest plan to defeat the Ghostbusters has his ghosts travel to the future and reprogram Morrow's robot Roballos for evil. Back in the past, the Ghostbusters are surprised to find themselves attacked by robots they believed to be good.

Tracy is captured by Prime Evil and placed in a machine which will replace all of his good memories with memories in which Prime Evil always wins and he always fails. That Ghostbusters work against time to bring the big ape back to normal.