When Allison Moore, the owner/head chef of a trendy Hamptons restaurant suffers a stroke, Hank attempts to save her from potential long-term damage, but she goes missing before treatment is administered. And on the day that Hank had previously planned to get married he spends time with Jill.

Boris flies Hank to another country, where he and another doctor research potentially life saving gene therapies. Back in the Hamptons, Hank's temporary replacement, Dr. Emily Peck, rubs Divya the wrong way.

Best friends worry about their line of house-cleaning products.

When a back problem limits Hank's ability to treat patients, Evan hires Dr. Van Dyke as a temporary replacement.

Hank and Evan heatedly compete for a new business opportunity. Meanwhile, Divya attempts to covertly reconcile the brothers' differences.

HankMed treats an absentminded country club manager while Evan, with Paige's help, lands the business opportunity he's always dreamed of.