We follow Mahiro Oyama, an unemployed good-for-nothing shut-in, who not only hasn't left the house in two years, but is also exceedingly addicted to gross video games. One afternoon, he wakes up and notices that his body feels a little off. Finding that strange, he goes to reach for his tablet, but what does he see in his reflection, but an adorable young lady. I wonder what lies in store for the "former" big brother, Mahiro as he's thrust headfirst into his new life as a girl.

As Mahiro stumbles through his new life as a girl, he finds himself gradually beginning to get into the swing of things. Realizing this, however, prompts him to try and reclaim some of his masculinity. He tries, in futility, to engage his core and do a sit-up, but ends up with a stomachache instead. Seeing his condition worsen rapidly before her eyes, Mihari has an epiphany. She realizes that his pain may actually have something to do with fact that almost a month has passed since Mahiro turned into a girl...

Mahiro makes a mad dash for the bathroom, but when he opens the door, he finds the facilities are already occupied by a high school girl he's never met. This bold fashionista turns out to be Kaede, Mihari's old classmate from middle school. Mahiro is initially a little nervous around her, but as he gets to know her, he learns how much of a nice person she is and becomes quite attached to her. Then, out of nowhere, Kaede asks "You've never done it before, have you?" and begins to scooch closer to a puzzled Mahiro. I wonder what she's about to do next...

It's Christmas and Mahiro is shocked to hear his own little sister has a date. Unable to shake his unease, he follows her through the festive hustle and bustle in secret, with Momiji as his escort in tow. Who could Mihari possibly be meeting with?

Mahiro and the girls take a trip to a Japanese inn over spring break. First they hit the town in their yukata, before heading to the open-air bath to detox. However, things go south when Mahiro begins to feel a familar tingling sensation between his legs.