Veteran reporter Roberto and rookie Meryl find themselves helping Vash the Stampede, an infamous thief with a bounty of six million double-dollars on his head.

Vash is in danger again now that ordinary townsfolk who have heard about the bounty are after him. As Vash tries to leave town, he runs into a family of heinous criminals who have broken out of prison and are now in a race to claim the bounty on his head.

Many years in the past, a colony ship traveling through space to find a new home for humanity suddenly experienced an emergency. Young Vash and Knives were saved by Rem and crash-landed on the planet No Man's Land on an escape pod.