Matlock is planning a birthday fishing trip with Leanne, but when he is called up for jury duty it puts a damper on their trip. Despite his convictions that no lawyer would want him on their jury, Matlock ends up being juror number six, and while everyone else on the jury wants to convict Travis Spaulding of the murder of his wife, Matlock alone thinks they need to take a closer look at the evidence before sentencing the man to death. Unfortunately, tempers flare in the jury room as the jurors soon become divided between guilty and not guilty.

While Cliff investigates a suit of medical malpractice and ends up getting more involved than he should with his client, Matlock investigates the case of the mysterious Rod Greenwood, who happens to bear an eerie resemblance to a dead businessman. Soon Cliff and Matlock realise that their cases are tied together.