Since Dr. Martin Nodel is the most brilliant geneticist in the world, the students and staff at the university are willing to put up with a few eccentricities -- unlike his son Paul, who gets impatient with his father's behavior. However, Dr. Nodel's behavior goes beyond eccentric after he unveils his research into introns, mysterious genetic material which he believes hold the code for future evolution. After a successful animal test, Nodel secretly tries the formula on himself, with amazing and disturbing results. As his intelligence begins to grow, so do scales on his hands, strange markings on his body, and a mysterious hole in his back. And he seems to be getting instinctive messages telling him to bring 'subjects' to a remote wilderness location. When he arrives there, accompanied by six students including Paul and his girlfriend, he finds a group of heavily armed soldiers and the key to unlocking a mystery that goes far beyond human science.

In this sequel to Double Helix, Dr. Ira Nodel (RON RIFKIN) has his body altered to communicate with aliens who have seeded Earth with their genetic material. He is joined on an alien spaceship by son Paul (Ryan Reynolds), Paul's girlfriend Hope (Kathleen Duborg), and six students. But, when Dr. Nodel touches a glowing post in the ship's control room, both he and Paul are consumed by a mysterious light. This leads Hope and the students to believe that they've been lead into a trap, a suspicion that is reinforced when the ship captures two of the students and pulls them through the wall. Desperate to find out what's going on, Hope reads Dr. Nodel's journal and risks her life by touching the glowing post. Her body begins the same transformation, and a strange glowing entity speaks in the voices of Dr. Nodel and Paul, trying to communicate with her. The ship, however, continues to snatch the students two by two.