Connor is stunned to find Alana, a female patient, is a pre-operative transgender. His resolve to cope is shattered when he subsequently learns that she used to be his football coach, and a mentor after Connor's father died. Repulsed and betrayed, Connor wants nothing more to do with Alana. Nor can he understand how Alana's son Tom, also an old friend, can be so accepting of the situation. Alana is diagnosed with breast cancer as a result of the hormone therapy she is on. She refuses to have a mastectomy and will not stop taking the hormones, as it would mean returning to the body she felt trapped in all her life. Connor confronts her for being a coward. Surely any life is better than none at all? Tom helps Connor appreciate the significance and bravery of Alana's transformation. Her distress over the injustice of her fate and insistence that she is still the person Connor admired, finally makes him accept not only the choice Alana has made, but Alana as a woman.

While Steph worries about her husband, Ben enjoys the freedom of being a separated man by flirting with a woman he is called to attend. However, innocent banter suddenly becomes serious when the woman offers her his phone number and then a lift home. Ben succumbs, ending up in bed, only to regret it.

Von refuses to heed Mitch's constant nagging that she must adjust her lifestyle to accommodate her lupus. Her day is not made any easier by Colin, a flamboyant chef who refuses to change his long hours, copious drinking and rich diet despite his diagnosis as a diabetic. Von is finally forced to read the riot act to him and can no longer ignore the relevance of the lecture to herself. Mitch drives the point home. If Von does not look after herself, she won't be able to hold down her job — and her work is the only thing Von has in her life. She goes home to begin educating herself about coping with lupus.

Terri learns Mitch is seeing an employee at All Saints. She becomes totally preoccupied with finding out the woman's identity, finally discovering it is Juliette, a physiotherapist. Mitch's refusal to divulge anything only frustrates her further. Not only is she cool towards Juliette, she is also snappy with her staff. Terri can't believe she has become the victim of the green-eyed monster and resolves to pull herself together, offering Mitch her genuine blessings for his future with Juliette.

Jared is the only nurse to readily accept caring for an obsessive-compulsive patient. At first, he and Sharon get on well, sharing their liking for cleanliness. However, as Sharon's condition becomes more and more trying, Jared starts to recognises some of his own behaviour in her. He tries his best to fight his own 'tidy' instincts, but is destined to fail.

Ben and Bron arrive at a shooting to find the victim is a Family Court judge, well known for his strong views on family values. Fearing whoever shot the judge will return to finish the job off, police arrange for him to be under strict police guard as he is taken off to All Saints. The police presence on the ward puts extra pressure on the nursing staff; it is not only the hassle of showing ID every time they enter the judge's room but the feeling that every person who walks on to the ward could be the one who shot him. The judge's son waits dutifully for him to return from theatre. On first impressions they appear to have a strong relationship. It is not long, however, before the cracks start to show. As police begin to suspect the culprit may be a lot closer to home than first thought, Nicholas reveals to Terri it was he who shot his father — having caught him in the arms of a woman other than his mother. Bearing the weight of his confession, Terri attempts to resolve the family dilemma. She finds herself entangled in a situation which, emotionally, resembles her own family. Her sympathy with the boy's feelings, if not actions, bring to the surface desires Terri had kept hidden in the deep cavities of her mind since childhood.

Luke and Bron spend their last morning together before Luke heads off to a so-called medical conference in Alaska. Bron, who thinks it is unfair doctors get to have all the fun, would do anything to join him. Out on the road with Ben, it is all Bron talks about. After transporting the judge to hospital, the pair is off to a backyard accident at a suburban house. Having injured herself while committing a mischievous act, 10-year-old Tess has hidden from her mother and is refusing to come out from under the house. Ben decides that, since Bron is the smaller of them, she should go under the house to drag the kid out. Bron does so and in the process receives a nasty cut (and, unbeknownst to her, a bite from a funnel web spider). When she returns to All Saints Bron goes for the regulation tetanus shot. Soon after she begins to feel woozy. Thinking it is her weak attempt at getting sick leave so she can go overseas with Luke, Ben teases her. It is not until she collapses that Ben starts to take her seriously. With Ben's help, Mitch diagnoses her condition. It is a tense wait as the anti-venom kicks in and Bron begins to recover. Seeing the girl they love so vulnerable makes both Luke and Connor realise how important she is to them. It is Connor who finds himself on the backburner, again, when Luke tells Bron he loves her.

Everyone is a little surprised when Simone Carlisle is admitted to hospital with a threatened miscarriage, not least of all Tony. Any ill feelings he has towards her are pushed aside, however, when he learns she has lost the baby. Simone's fiance, Darren, is keen to try for another child straightaway. Mitch warns Simone against this, advising that the management of her hepatitis C must take priority over becoming pregnant. Mitch says Darren needs to be aware of her condition, especially if he is to be her life partner, but Simone is afraid of revealing her past to Darren, and risking losing the man she loves. With Mitch's support, she tells Darren about her hepatitis C status, and her history of IV drug abuse. Her worst fears are realised when Darren walks out. It is Tony who helps Simone find the strength to face life alone.

Von covers for Jared, who is suffering the effects of a strenuous gym routine.

Gabrielle Flanagan is admitted onto Ward 17 to donate bone marrow for a 12-year-old girl with leukaemia. On hearing her name, Von and Steph both wonder if it is "the Gabrielle Flanagan" — a woman whose baby daughter was stolen from her 10 years ago. Connor's curiosity is aroused. He is dying to ask Gabrielle — who is his patient — if she's the one. He does not have to wonder for long as Gabrielle, being highly strung and paranoid after so much time in the media spotlight, informs him that it is indeed her. Although they have got off to a bad start, Connor's sympathy grows as Gabrielle tells him about the never-ending quest to find her daughter, whom she believes may still be alive. Gabrielle shows Connor an image projection of what her daughter would look like now at age 12. Connor thinks it is uncanny that the picture looks very similar to the 12-year-old patient Alex, who is also in the Ward, to receive Gabrielle's bone marrow.

Jared tells Connor that Alex is adopted and they start to wonder if she could be Gabrielle's daughter — right age, exact bone marrow match, the likeness in the image projection picture. Gabrielle encounters Alex in the hospital grounds and is amazed at the resemblance to what her daughter should look like. She pesters Connor for details and when he can't tell her anything she manages to sneak a look at Alex's file. When she learns it is Alex who will be receiving her bone marrow she is convinced she is about to be reunited with her long lost baby girl.

Meanwhile, Alex Richards is devastated to learn from her parents she is adopted. She cannot understand why her parents kept it a secret from her — obviously they must be ashamed of her. Terri manages to convince the girl to listen to her parents' explanation of why they chose to lie to her.

Kevin Simms is admitted to the Ward suffering advanced emphysema. He is in a bad way and Mitch has to tell him he only has a short while to live. But Kevin is desperate to make it one extra week. He has put in for a marriage certificate so he can marry Liz, the woman he loves. Making her his wife is the only thing that will allow Kev to rest in peace — he wants to will his house to her but he is sure that his nasty sister is going to contest it. However, if Liz is his wife, his sister Maisie won't have a leg to stand on. Tony, who is feeling very depressed about his Hep C, discovers that in special circumstances a marriage licence can be rushed through. Tony seems to get a new lease on life as he sets about organising a perfect wedding for Kev and Liz. The only question is… will Kev stay alive long enough to make it to the altar?

Bron and Ben attend what has been described to them as a domestic dispute. A frantic man, Raymond, meets the ambulance and tells them he's stabbed his best mate Trevor. He thinks he has killed him! Bron and Ben race in side and are more than surprised by what they find.