It's November 1967 and nurse Colleen McMurphy faces the last week of her tour of duty in Vietnam, dealing as usual with the dying boys, primitive conditions, and the sexual pressure from pilot Natch Austin. USO singers Georgia Lee and Laurette Barber arrive to entertain the troops in the base's new R&R center. Brand new Red Cross volunteer Cherry White also arrives, determined to find her brother, a marine no one can locate.

McMurphy decides that she can't leave China Beach even though she is eligible to go home. Cherry and Laurette arrive- Cherry to look for her brother whom her family lost contact with and Laurette as a USO back up singer who gets promoted to lead when the lead singer can't cope with the war.

Despite distractions, McMurphy and Natch finally get together. Laurette gets a chance to join another, bigger USO tour. McMurphy gets blamed for a body that disappears on her shift.