Danny Fenton is losing his mind! At least, that's what Jazz decides when her little brother starts acting strangely and fighting ghosts that aren't there. In reality, Danny is being tormented by a revenge-seeking Youngblood, who cannot be seen by adults -- or by big sisters who think they're adults. When Jazz sells the family on a ghost-tech-free camping trip, Youngblood follows and unleashes a series of juvenile attacks that make Danny seem even crazier, and put the Fenton family in danger.

Skulker's on a looting spree, snatching up a number of seemingly unrelated items. Unfortunately, Danny's attempts to stop him are thwarted by the well-intentioned meddling of Danny's new sidekick: Jazz. However, Danny didn't ask for -- and doesn't want -- Jazz's help, and after a series of humiliating mishaps, Danny blows up at his sister. In response, Jazz runs away from home... to Vlad's castle in Wisconsin! But it's only a ruse. Jazz soon manages to break into Vlad's inner sanctum and discovers that he has been using Skulker to collect the items necessary to upgrade the Fenton's stolen Ecto-Skeleton. When Danny arrives at the castle, Vlad makes Jazz don the improved battle suit in a no-holds-barred fight against Danny Phantom!

Tucker's running for student body president, but no one's paying his campaign any notice, and that includes his campaign managers: Danny and Sam. On a field trip to a museum to look at ancient Egyptian artifacts, everyone is surprised that the pharaoh in question looks just like Tucker. And when Tucker looks in a ghostly mirror, his image brings the pharaoh's minion, Hotep Ra, to life! Hotep Ra bows before Tucker and becomes his servant, urging him to not stand by anymore and be ignored. Tucker's new attitude -- with help from his new king's scepter -- gets him even more respect than he expected when he accidentally transports his friends and classmates to ancient Egypt during a school debate. Now, Tucker is a king, and it's hard not to enjoy the perks. Unfortunately, the servant Hotep Ra has his eye on Tucker's throne and some sinister plans in mind for the students of Casper High.

The Fentons sell Fenton Works to the Guys in White who plan to destroy the Ghost Zone (unaware that Earth will be destroyed too) with a missile; meanwhile, Danny starts to let the rich life get a hold of him and jeopardize his friendship with Sam and Tucker.

Danny and Vlad’s game of revenge against each other begins with childish pranks, and, unfortunately for Danny, ends when Vlad decides to run for mayor of Amity Park! By overshadowing voters, Vlad wins in a landslide. The new mayor is eager to use his new power to make life as miserable as possible for Danny and his friends. He shuts down the Nasty Burger, outlaws technology, creates new school uniforms, and passes so many new laws in the name of “protecting the children” that Danny finds it impossible to go ghost.

Danny's class goes to a camping trip with Mr. Lancer and Ms. Teslaff to an abandoned place which is seemingly haunted. Soon reports of monster sightings and missing students have the whole camp shook up. Monsters start showing up and disrupting the camping trip. To Danny's surprise, these monsters are ghosts working for Walker, on the hunt for Wulf. Now Danny must save his old friend and his class from Walker!

Danny, after being publicly shamed by Vlad's new ghost hunting team, wants to be normal again. So he gets rid of his powers by reactivating the Fenton Portal after Jack dismantles it for a software upgrade. However, an asteroid made of Ectoranium threatens the Earth, and Vlad - after revealing to everyone that he is Plasmius - fails to stop it. The world now relies on a powerless Danny to get help from the ghosts in the Ghost Zone!