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Rob Lake starts work at the Obstetrics and Gynaecology Department at the South Central Infirmary as a new registrar. There he encounters problems from the start including one woman who almost gets the wrong operation after a communication error. Later, things go from bad to worse after a woman dies when Rob has to perform an operation on her throat that he isn't trained to perform! Also, Dr Maria Orton approaches Rob about his supervisor Roger Hurley who she believes is incompetent and only got his job because of the amount of research he does. Karen Taylor is admitted to the ward. She is bleeding internally and requires an operation. Roger performers the operation but things go wrong. Karen is left brain damaged and her child ends up dead and the baby's father, Karen's husband, wants answers.

When another of Hurley's operations starts to go wrong, a desperate Rob persuades Whitman to intervene. But what will the consequences be of his betraying a fellow doctor?

As their relationship grows progressively more difficult, Rob tries to persuade Hurley to admit to his bungled operation. However, when Hurley goes to management, Rob is forced to attend a hearing about his own mistakes. Meanwhile, a drug mix-up leaves a patient in a coma and Rob's secret affair with Donna becomes more intense.

With Rob on suspension, Polly faces a terrible dilemma when Hurley's bid to meet hospital targets endangers the life of a mother and her baby. The Taylor case comes before hospital management, but will they succeed in getting compensation?

Rob and Dr Hurley must put aside their differences to save the life of a baby during the process of birth. Meanwhile, Dr Whitman makes a pass at Polly, and Maria Orton faces a psychiatric assessment due to her allegations against Hurley.

Rob reaches breaking point haunted by the fact that he killed a patient. Hurley bungles another woman's care, yet remains in line for a promotion. Whitman faces a charge of sexual harassment.

In the series two opener, Rob is about to leave South Central Infirmary and is still seeing Donna on the sly. However he has no job lined up and the future doesn' t look to bright for him. Meanwhile, Roger Hurley has been promoted to clinical director but keeps clashing with Tony Whitman.

Tim Sibley is working on the gynae ward with Polly and is hoping this work will help him get a job with Whitman's firm. Elsewhere Chrissy , the new department manager, wants to know why Rob is leaving since he has more capablities of doing the job than Tim does. Rob asks Hurley for a reference and then Donna tells him she wants to end their affair.

Whitman has gotten on the wrong side of Chrissy after catching him in the female changing room. At the monthly M&M meeting, Hurley places Rob in a position to speak out against Whitman in front of the entire department.

Whitman is still holding a grudge against Rob and will not help in a major medical situation. Chrissy is still digging up dirt against Whitman who refuses to operate on a patient in case something goes wrong. Elsewhere, Rob and Donna's relationship proves to be so stressful that Donna turns to Diamorphine for help.

Donna becomes continues vocalizing her disagreements with Hurley. Chrissy receives anonymous letters about Hurley's negligence and everyone assumes it's Donna. Meanwhile, one of Whitman's patients dies or does she?

The HRPU opens and during the speeches Hurley announces a new Clinical Fellowship position that interests both Rob and Polly. The competition between them soon leads to mistrust. Chrissy approaches Tennant about the anonymous letters she's been receiving but he doesn't take them seriously and the repercussions aren't what Chrissy anticipated. Donna's anger and mistrust towards Hurley is growing. However,Rob stops her from going a bit too far and explains that when the time comes to 'bring him down' it'll be his decision, no one else's.

Hurley gets his sperm test results back, and it's not good news. Meanwhile, Rob has his hands full with a woman who is pregnant with five babies. He knows that they should go for a selective reduction, but Hurley feels the pressure from management for a media friendly story, and agrees to go with the woman's wishes to try and take the pregnancies to term, despite the risks involved.Hurley and Whitman both speak at a medical symposium, but the real action is in the hotel later that evening involving Hurley and Maya.

Polly finds out she’s pregnant and thinks she can deal with it herself.Tim and Whitman perform a termination procedure. When the woman returns with an infection, Tim goes out of his way not to help her. Throughout the day, Whitman is being assessed. The final test is a difficult case requiring excellent operating skills. He impresses Hilary Sachs with an unexpected theatre emergency.Rob has something important he must tell Beth and Donna and everyone wants to know what happened to Hurley and Maya in the hotel room.

A patient is re-admitted with heart problem and Whitman is convinced it has to do with the drug trial she's been on. Also, it's exam time for Rob and Polly, however only one of them can get the prestigious Clinical Fellowship. Also, Hurley receives a mystery text message, making him even more paranoid. His mind's not on the job when he fails to recognise the symptoms of a woman with terrible abdomen pain. Later, Harriet turns up at the hospital and tells Hurley he needs to move out for a while.

Whitman officially takes over from Hurley as the acting Clinical Director, and must endure a very difficult day.Polly is feeling guilty that she got the Clinical Fellowship job on the back of her research into the FSD drug and Rob’s had enough and tells Donna he wants to leave the hospital, that is until he is unfortunately summoned to a secret meeting with Tennant and Hurley, where he is made a very tempting offer.

Fast-forward three years and a lot can change. Rob Lake's got a new position in a different hospital. And he is about to become a father. But one thing remains the same -- Dr. Roger Hurley is still practicing.