After telling his mother, he wanted to leave school for good, seventeen year old Andy Deaver vanishes from his private boarding school, last seen by it's headmaster, Graham Spaulding.

A girl vanishes from a psychiatric hospital, and it appears she may have escaped with a staff member. Then the team learns of a troubling incident from her past that may hold the key to her disappearance.

The team is baffled as to why no family members come forward after a Latino boy is abducted in mildde of the day time from a street in Spanish Harlem.

The team searches for a man who goes missing after leaving his wife's hair salon to deposit the day's earnings following an argument with her. Meanwhile, Danny resists getting pulled back into the life of his convict brother who is up for parole, and Martin's impending firearms qualifications test dredges up unsettling memories for him.

When Mac, a prisoner only two weeks from parole, disappears during a fight in the yard along with another prisoner, his sister contacts the FBI for help. No one can figure out why a member of the Aryan gang would escape with a black prisoner. While Martin and Viv talk to the other prisoners and Jack tries to wade his way through the sister's lies and half-truths where her brother is concerned, Danny focuses on a new prisoner who Mac had been protecting.