An inner city youth club is threatened when a black resident is framed for auto theft by a neighborhood racist who'll stop at nothing to close the center—even murder.

MacGyver heads up a trip with four other Phoenix Foundation employees into the wilderness as part of a stress reduction program. After discovering that a prison bus accident has freed several prisoners, the employees begin to question each other's behavior. MacGyver must now figure out which man, if any, is not to be trusted before it's too late.

MacGyver works hard to retrieve the anthrax bacillus stolen by a former Navy commando who once saved his life, and is now suffering the effects of an old head wound.

During some tough negotiations between two neighbouring states, one side plants a sniper in the vicinity. When Mac discovers the sniper, he fights him, but loses the man and the accusations go out against Mac. Wounded and forced to run, he hides at a private girls' school, where one of the young ladies becomes his only hope to prevent further bloodshed.

MacGyver and a friend race with a group of dedicated guerillas to locate a valuable Incan treasure.