When MacGyver tries to retrieve a canister filled with a deadly chemical in Burma, he stumbles right into an area known as the Golden Triangle, where the military uses farmers as slaves on the opium fields. MacGyver is mistaken for a narcotics agent and is captured, but convinces the slaves to fight their oppression. MacGyver assists by setting several traps at the slave camp, and when the army returns to suppress the unrest, the real action begins.

MacGyver comes along on a expedition to Brazil with his friend, entomologist Dr. Alden. They meet with a landowner and recluse, Trumbo, who is initially hostile. However, when they realize that a mile-wide column of army ants is moving through the jungle, they team together to mount a defense.