When MacGyver tries to retrieve a canister filled with a deadly chemical in Burma, he stumbles right into an area known as the Golden Triangle, where the military uses farmers as slaves on the opium fields. MacGyver is mistaken for a narcotics agent and is captured, but convinces the slaves to fight their oppression. MacGyver assists by setting several traps at the slave camp, and when the army returns to suppress the unrest, the real action begins.

MacGyver travels to Budapest to meet with a Russian double agent who is in possession of a watch containing information about other Russian spies. However, before MacGyver can take the watch, the agent is killed and the watch is stolen. Now MacGyver must work with the Gypsies to get it back.

MacGyver attempts to get a reporter out of a Central American country with evidence linking a general to an illegal arms dealer. As they reach the border, it is clear escaping to Mexico will be no easy task, as the general and the arms dealer have every imaginable route severely guarded.

When $60 million worth of stolen diamonds destined for a relief charity end up in the hands of casino owner Jack Catlin, MacGyver must head to the Virgin Islands to try and get them back. With the help of Chris Rhodes, a senator's daughter, MacGyver masterminds a plan to break into Catlin's vault and steal them back.

MacGyver comes along on a expedition to Brazil with his friend, entomologist Dr. Alden. They meet with a landowner and recluse, Trumbo, who is initially hostile. However, when they realize that a mile-wide column of army ants is moving through the jungle, they team together to mount a defense.