In the series pilot, social opposites Sam and Brooke are paired as lab partners, to the delight of Carmen, who sees it as a chance for Sam to help her get on the cheerleading squad. Meanwhile, Brooke and Nicole plan the first party of the school year and star quarterback Josh tries out for the school play.

Carmen ditches school the day after the cheerleading roster is posted, and Lily refuses to dissect a frog in science class. Meanwhile, Josh's father embarrasses him at rehearsal; and Mary Cherry stalks Nicole.

Brooke, Poppy, Mary Cherry and Carmen are nominated for the Junior Court Homecoming Queen and Nicole pressures two of Brooke's opponents to halt their campaigns. Meanwhile, Sam and Jane move into the McQueens' house, causing an instant turf war between Brooke and Sam.

Brooke and Sam are forced to hold their annual Christmas parties together, and Carmen is injured just weeks before the next round of cheerleader tryouts. Meanwhile, Nicole's brooding over the yuletide season leads to visits from the ghosts of Christmas past, present and future.

Emory puts the popular kids, Bobbi Glass and the lunch lady on trial for harassing him. Sam and Lily volunteer to represent him at the school's mock proceeding, which leads Principal Hall to ask Brooke to lead the defense. Meanwhile, Josh and Sugar look forward to the start of the wrestling season.

Principal Hall forces Josh, Harrison and Sugar Daddy to attend a weekend sensitivity camp after they harass a scantily clad Lily. Sam and Brooke work on the school's crisis hot line and inadvertently heighten one of the caller's problems.