The girls' jeep gets sabotaged, forcing them to stop in a nearby village for the night. There, Ellis gets kidnapped by a bounty hunter assisted by a local girl who dreams of going to the city, prompting Nadie to mount a rescue.

Nadie and Ellis encounter a village where denizens worship a fake witch. With danger of being discovered as a fake, the woman tries to befriend Ellis in order to strengthen her own position. When the townspeople discover the truth, they come to her mansion, demanding the money she has swindled out of them.

The heroines meet Ricardo and Lirio in an abandoned hot spring hotel. There they learn that Ricardo is now out of a job, as Rosenberg is forced into early retirement in order to eliminate any link between Project Leviathan and the Central Intelligence Agency. Following these events, the organization that Blue-Eyes works for decides that instead of having Ellis assassinated, they would bring her in. Nadie, however, has other ideas.

L.A. arrives in a town bar, and after being irritated by some of the bar's patrons, kills several of the people there. When Ellis and Nadie arrive in the same town, the police there arrest Nadie and throw her in prison. Under Nadie's orders to escape, Ellis runs off and joins Ricardo and Lirio. L.A. appears at the police headquarters and reveals that he's using the police to separate Nadie and Ellis. Ellis, Ricardo, and Lirio attempt to free Nadie, but L.A., having killed the two policemen at the HQ, decides to kill Nadie before that. Nadie, having taunted L.A. about how human he seems despite having a hatred for them, is saved by Ellis before he's able to kill her. As a last-ditch attempt to separate them, L.A. reveals why Nadie originally approached Ellis, but his attempt backfires when Ellis declares that no matter why she did, Nadie is most important to her. With this, L.A. flees defeated in both his plan and his desire to win Ellis's heart.

Ellis and Nadie arrive at Wiñay Marka (in which they've been seeking, and which has a strong resemblance with Machu Picchu) and meet up with Rosenberg. Reciting the witches' ancient lore, Rosenberg takes control of Ellis's powers and uses them to harm Nadie. With Nadie nearing death, Ellis requests that she kill her so that she can't be harmed by Rosenberg. Nadie reluctantly and tearfully accepts the request, and Ellis declares her love for her. However, even after Ellis is killed, Nadie dies shortly after from her injuries. Ricardo, Lirio, and Blue Eyes arrive and with some help from Lirio, Blue Eyes's witch powers awaken and with them, she revives Ellis who in turn revives Nadie. With the cave collapsing, Ellis and Nadie pursue a fleeing Rosenberg. With the two girls facing off against him, Ellis, with Nadie's support, recites Nadie's favorite saying before shooting Rosenberg and ending the threat of Project Leviathan for good.