Although stung with poison herself, Granny Chiyo uses the last of the antidote on Sakura. Mocking the tender scene between Granny Chiyo and Sakura, Sasori attempts to end Granny Chiyo's life.

Naruto, Choji and Shikamaru attempt to capture and interrogate Sai, but Sai withdraws after insulting Naruto. Shortly afterward, Ino appears. Concerned that the demon fox could fall into Akatsuki hands, the village elders challenge Tsunade's plan to send Naruto out of the village without the still bedridden Kakashi. Tsunade promises to protect Konoha with her own life if Naruto is captured, but is still forced to compromise with Danzo by adding Sai to Team Kakashi. She also temporarily replaces Kakashi with ANBU member Yamato and warns him to keep an eye on Sai. Naruto and Sakura finally meet their new team members, and Naruto is immediately angered upon Sai's appearance.

Kabuto comments that Naruto's state is a consequence of his desperation to bring back Sasuke. Sakura begins to cry and approaches Naruto but is injured when his attention turns to her. Yamato uses the mokuton jutsu to bind Naruto before he does any more harm. Kabuto heals Sakura, reasoning that the Konoha ninja are not Orochimaru's enemies because they are also fighting Akatsuki. Yamato uses the abilities of the 1st Hokage to forcibly return Naruto to his normal state. Meanwhile Sai confronts Orochimaru with a message from Danzo. Orochimaru responds by piercing Sai with Kusanagi.

As Team Kakashi continues their search for Sasuke, Naruto suddenly collapses due to his previous fight with Orochimaru. As Naruto wakes up, Sai begins to reveal more about his brother, but Orochimaru suddenly attacks them. Sakura and Yamato come to Naruto's aid against Orochimaru, while Sai continues the search. Just as Sai finds Sasuke, Yamato finds Sai's bingo book with Sasuke listed as a target for assassination.