Karin is caught within the Infinite Tsukuyomi and dreams of her past. She was born into the Uzumaki Clan and has the unique ability to heal anyone who bites into her. Driven out of her village, the Hidden Grass takes her in, only to use her for this ability. Karin has no choice but to endure constant suffering in order to survive. She is later chosen to enter the Chunin Exams, where Sasuke saves her life. Karin has never forgotten what he did for her—or his smile.

Sasuke and Sakura join up with the others, but the Puppet User appears and blocks their path back to the Hidden Leaf Village. Sasuke wants to bring down the puppets and rush back to report to the Fourth Hokage, but Shikamaru and the others insist on staying and rescuing the jonin.

Seeing Hinata almost die triggers Naruto’s anger and he goes into Nine Tails State. Naruto's power is enormous, but Pain releases his jutsu to seal him away. Hatred consumes Naruto as he tries to break the seal. With Naruto unable to calmly control the Nine Tails’ power, the village steadily heads toward destruction.

Itachi becomes a rogue ninja and joins the Akatsuki. He is welcomed and introduced by Pain and Orochimaru as the ex-Leaf ANBU and the man who massacred his entire clan. Itachi is paired up with a man named Juzo, and their first job together is to fulfill an assassination request in the Land of Water.

Chakra—whose energy connects this world to those beyond—allows Obito to leave Rin's side for a moment and appear in Kakashi’s inner psyche. Obito gives him his Magekyo Sharingan and leaves with a parting wish that Kakashi become the Sixth Hokage.