After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

In a violent clash with Greed, King Bradley proves to be a brutal opponent. But the man who finally destroys the Ultimate Shield is more powerful than even the Fuhrer himself.

Mustang, Alphonse, Havoc, and Hawkeye split up to search a military laboratory. If Lust has her way, none of them will ever see each other alive again.

Long ago, the blood of a simple slave was used in an experiment which created a strange, shapeless being. In exchange for the gift of existence, the being gave the slave a name - and cursed him with immortality.

After a startling radio broadcast grants Mustang's forces the advantage over Central's troops, the Flame Alchemist unleashes the brutal power of burning hatred in the battle against the killer of Maes Hughes.

As Envy writhes within the firestorm unleashed by Mustang's vengeful rage, Hawkeye must take drastic measures to prevent the Flame Alchemist's hatred from burning out of control.

As the light of the sun vanishes, Mustang learns the loss which comes from seeing the other side of the Gateway - and five sacrifices gather in the dark presence of the Father.

The light is gone. Shadows swallow everything. As the planet quakes and the heavens tremble, the souls of heroes and villains alike vanish into darkness. The circle is complete.

As one shared journey ends, many journeys begin. Those most touched by the conflict which surrounded the Philosopher's Stone now go their separate ways. One thing is certain: they will meet again.