Ed and Al become interested in biological transmutation after witnessing a chimera in Lior, so Colonel Mustang introduces them to an expert in the field, Shou Tucker, the Life-binding Alchemist. Meanwhile, a serial killer whose targets are only State Alchemists is on the loose in Central.

After learning about what happened to Shou Tucker and his daughter Nina, the Elric brothers begin to question what alchemy really is. Meanwhile, Colonel Mustang and the other State Alchemists track down the serial killer Scar.

When Ed and Al arrive at the Central Library they discover that it has been burnt to the ground and instead are taken to see Sheska, a former employee who may have the information they seek. Meanwhile, in East City an unexplained explosion causes Colonel Mustang to restart his search for Scar.

Ed and Al sneak inside the Fifth Laboratory to search for more answers about the origins of the Philosopher's Stone. However, it is not long before they are each attacked by former death row murderers who now guard the complex.

Ed is now in a hospital recovering from his wounds and Al is unable to let go of what Number 66 told him back at the Fifth Laboratory. Meanwhile, Winry agrees to make a trip to Central in order to repair Ed's automail... again!

When the conspiracy surrounding the Philosopher's Stone closes in on the highest ranks of the military, one of Mustang's most trusted and cherished allies is murdered.

After learning of Hughes's fate, Ed and Al are ravaged by sadness and guilt. Envy still hides in plain sight among the State Alchemists, and another Homunculus is on the verge of infiltrating their ranks as well.

Freed by an unlikely liberator, Ross's escape is interrupted by Mustang. Even those most loyal to the Flame Alchemist are shaken by the controversial action he takes against the accused killer of Maes Hughes.

Ed's journey to a distant land of legend offers surprising new details behind Mustang's alleyway encounter with Ross. After a fateful encounter of his own, Elric learns a stunning secret about Winry's parents.

Hoping to learn more about the Homunculi, Ed and Al devise a risky strategy to lure the creatures out of hiding. Step one of the brothers' plan: risk death at the hands of their most dangerous enemy - Scar.

Mustang leads a ragtag assault force of hardy northern troops - and welcome faces from the past - against Central's defenses. Victory seems certain until the military's most horrifying secret is revealed.

Ed's crew faces a horde of ravenous mannequins, abominations powered by human souls. The twisted creatures aren't the only unstoppable force on the battlefield -Pride, Sloth, and Envy are on the move.

With a Philosopher's Stone in his possession, Alphonse fearlessly engages Pride and Kimblee. Elsewhere, the Armstrongs find themselves trapped between Sloth's onslaught and the guns of Central's troops.

After a startling radio broadcast grants Mustang's forces the advantage over Central's troops, the Flame Alchemist unleashes the brutal power of burning hatred in the battle against the killer of Maes Hughes.

Central's forces fight with renewed vigor following Bradley's return, and the Fuhrer himself enters the battle. His first opponent is an armored tank. His second foe is even tougher.

The light is gone. Shadows swallow everything. As the planet quakes and the heavens tremble, the souls of heroes and villains alike vanish into darkness. The circle is complete.

As one shared journey ends, many journeys begin. Those most touched by the conflict which surrounded the Philosopher's Stone now go their separate ways. One thing is certain: they will meet again.