Baretta is investigating a mob theft of diamonds belonging to Mr. Nicholas and winds up helping a merchant who is threatened by a new group in the neighborhood called the East Side Benevolent Society, who is forcing all the shop owners to pay money for protection or suffer the consequences.

Pursuing a gunrunner with spinal meningitis, Baretta becomes infected and has 48 hours to find the man and his cohorts before he has to go into quarantine.

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An FBI computer expert poses as a field agent to join Baretta on a case regarding stolen emeralds that led to murder.