In the second-season opener, the team hunt a merciless serial killer whom Lloyd's testimony helped convict. Meanwhile, Charlie gets offered a promotion, putting the fate of the program in jeopardy.

A female prison volunteer is attacked by a rough female inmate. On the way to the court hearing that is a result of that attack, the inmate takes ill at a very precise time. The transport is forced to turn into a rest stop, where the inmate escapes. When the inmate shows up at the home of the volunteer and stabs her husband it appears tragic, until it's learned the volunteer and inmate had been working together. The Breakout Kings are in hot pursuit of this "Thelma and Louise-like" duo as they make a run for it.

Ex-Navy SEAL Jonah Whitman makes a gruesome escape from prison. His mental health is in question and he’s considered to be armed and extremely dangerous. Rather than run, though, Jonah proceeds to exact revenge from his former employers at ALASTOR, a government contractor that sets conspiracy theorists buzzing. The Breakout Kings track Jonah and attempt to bring him in, while uncovering the truth behind his paranoia.

Max Doyle was an orphan raised in the circus with an ax to grind. All his life Max has felt a lack of belonging, a feeling that was only partially assuaged by turning himself into a premiere escape artist. It's that talent that the Breakout Kings are up against as they track Max. Meanwhile, not all of the Kings are on the case, at least one stays back to follow a clue left by their nemesis Damien Fontleroy - with disastrous consequences.

The conflict between Damian Fontleroy and the Breakout Kings comes to a head when Damian abducts Ray's daughter.