Following what Sam has seen as a vision, Sam and Dean visit their childhood home in Lawrence Kansas. Sam and Dean discover an unseen force is terrorizing the current residents of their house, a mother and her two children.

Lady luck? Not really. Sam and Dean stop by Las Vegas for a little fun and relaxation -- plus to try their hand at the tables. But bad luck soon befalls Dean, and there is some strange guy following him.

Dean visited Missouri because he struggled with the true meaning of John's last words... "Save Sam, or kill him". Some old photos remind Dean of Mrs. Lyle, who was Sam's teacher. He remembers how he and his father saved Sam, despite what his future held.